@kas1e (maybe @capehill, but i guess it's more of a GLES2 problem?)
I found a glitch with cursors on using OpenGL with shaders.
With the latest release (ScummVM) and the current gles2.library (non-beta-testers) i get a glitch in in-game cursors (right now i only have Nippon Safes Inc. to test - Amiga version...i'm sure you can get a copy).
Using "Software" as renderer, all is fine, using "OpenGL with shaders" the cursor is broken (switching to window will make it vanish completely and not come back) see screenshot
Could you test with your beta gles2.library, please?
The blob on the left should be the cursor...